V900833
Hyaluronidase from bovine testes
Vetec™, reagent grade
Synonym(s):
Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase
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About This Item
CAS Number:
UNSPSC Code:
12352202
EC Number:
253-464-3
MDL number:
Specific activity:
≥750 units/mg solid
Biological source:
bovine testis
biological source
bovine testis
conjugate
conjugate (Glucosaminoglycan)
grade
reagent grade
product line
Vetec™
form
powder
specific activity
≥750 units/mg solid
storage temp.
−20°C
Biochem/physiol Actions
These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.
Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
Other Notes
One unit will cause a change in A600 of 0.330 per minute at pH 5.7 at 37 deg C in a 2.0 ml reaction mixture.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Explore the role of hyaluronan, hyaluronic acid structure, hyaluronan synthesis & degradation, and more. Find GAGs, hydrogels, and scaffold kits.
Xuebo Pan et al.
Cell metabolism, 27(6), 1323-1337 (2018-05-01)
Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. However, the role of FGF21 in hypertension remains elusive. Here we show that FGF21 deficiency significantly exacerbates angiotensin II-induced hypertension
Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase.
O Shpilberg et al.
British journal of cancer, 109(6), 1556-1561 (2013-09-05)
Rituximab and trastuzumab were the first therapeutic monoclonal antibodies (mAbs) approved in oncology. Both antibodies are delivered by the intravenous (IV) route, but recently subcutaneous (SC) formulations have been developed. Subcutaneous administration of mAbs can offer substantial patient and resource
Gry Hulsart-Billström et al.
Biomacromolecules, 14(9), 3055-3063 (2013-08-21)
Regeneration of bone by delivery of bone morphogenetic proteins (BMPs) from implantable scaffolds is a promising alternative to the existing autologous bone grafting procedures. Hydrogels are used extensively in biomaterials as delivery systems for different growth factors. However, a controlled
Global Trade Item Number
| SKU | GTIN |
|---|---|
| V900833-100MG | 04061832844978 |
| V900833-50MG | 04061832844985 |