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V900931

Trichostatin A

Name: Trichostatin A
Brand: VETEC

From Streptomyces sp., ≥98%, HDAC inhibitor

Synonym(s):

Trichostatin A, TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₂N₂O₃

CAS Number:

58880-19-6

Molecular Weight:

302.37

PubChem Substance ID:

329830233

UNSPSC Code:

12352200

MDL number:

MFCD03848392

Assay:

≥98%

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Properties

Product Name

Trichostatin A , Vetec^™, reagent grade, from Streptomyces sp., ≥98%

biological source

Streptomyces sp.

grade

reagent grade

product line

Vetec^™

assay

≥98%

storage temp.

−20°C

SMILES string

C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C

InChI

1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

InChI key

RTKIYFITIVXBLE-QEQCGCAPSA-N

Description

Biochem/physiol Actions

Trichostatin A (TSA) inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. Trichostatin A serves as an epigenetic modifier.

Trichostatin A inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

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The role of Sox6 in zebrafish muscle fiber type specification.

Harriet E Jackson et al.

Skeletal muscle, 5(1), 2-2 (2015-02-12)

The transcription factor Sox6 has been implicated in regulating muscle fiber type-specific gene expression in mammals. In zebrafish, loss of function of the transcription factor Prdm1a results in a slow to fast-twitch fiber type transformation presaged by ectopic expression of

Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification.

Masato Yuasa et al.

The Journal of clinical investigation, 125(8), 3117-3131 (2015-07-28)

Bone formation during fracture repair inevitably initiates within or around extravascular deposits of a fibrin-rich matrix. In addition to a central role in hemostasis, fibrin is thought to enhance bone repair by supporting inflammatory and mesenchymal progenitor egress into the

MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells.

A Formosa et al.

Oncogene, 33(44), 5173-5182 (2013-10-30)

miRNAs act as oncogenes or tumor suppressors in a wide variety of human cancers, including prostate cancer (PCa). We found a severe and consistent downregulation of miRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to

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Global Trade Item Number

SKU	GTIN
V900931-1MG	04061826746073
V900931-5MG	04061826746080