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902039

4-Methoxypicolinimidamide hydrochloride

Name: 4-Methoxypicolinimidamide hydrochloride
Brand: ALDRICH

≥95%, powder or solid

别名:

Weix 2-pyridylcarboxamidine ligand for nickel catalysis

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关于此项目

经验公式（希尔记法）:

C₇H₁₀ClN₃O

化学文摘社编号:

1179361-66-0

分子量:

187.63

UNSPSC Code:

12352101

NACRES:

NA.22

MDL number:

MFCD12755550

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属性

产品名称

4-Methoxypicolinimidamide hydrochloride, ≥95%

assay

≥95%

form

powder or solid

reaction suitability

core: nickel, reaction type: Cross Couplings, reagent type: catalyst

mp

174-176 °C

SMILES string

Cl.N\C(=N/[H])\c1nccc(c1)OC

InChI

1S/C7H9N3O.ClH/c1-11-5-2-3-10-6(4-5)7(8)9;/h2-4H,1H3,(H3,8,9);1H

InChI key

JOUDWIBACXLPIO-UHFFFAOYSA-N

说明

Application

This pyridyl carboxamidine ligand has been demonstrated by Daniel Weix′s lab to enable nickel-catalyzed cross-coupling of diverse basic nitrogen heterocycles with primary and secondary alkyl halides.

Other Notes

Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling

New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries

Electrochemical Nickel Catalysis for Sp²-Sp³ Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Electrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides.

Robert J Perkins et al.

Organic letters, 19(14), 3755-3758 (2017-07-14)

A constant-current electrochemical method for reducing catalytic nickel complexes in sp2-sp3 cross-electrophile coupling reactions has been developed. The electrochemical reduction provides reliable nickel catalyst activation and turnover and offers a tunable parameter for reaction optimization, in contrast to more standard

Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling.

Eric C Hansen et al.

The Journal of organic chemistry, 82(14), 7085-7092 (2017-07-07)

Despite their importance, the synthesis of alkylated heterocycles from the cross-coupling of Lewis basic nitrogen heteroaryl halides with alkyl halides remains a challenge. We report here a general solution to this challenge enabled by a new collection of ligands based

New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries.