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913839

2-Methylnicotinic acid imidazolide

Name: 2-Methylnicotinic acid imidazolide
Brand: ALDRICH

别名:

(1H-imidazol-1-yl)(2-methylpyridin-3-yl)methanone, 1H-Imidazol-1-yl(2-methyl-3-pyridinyl)methanone, 3-(1H-imidazole-1-carbonyl)-2-methylpyridine, NAI, RNA SHAPE probe, RNA structure probe, mNAI

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关于此项目

经验公式（希尔记法）:

C₁₀H₉N₃O

化学文摘社编号:

1055970-47-2

分子量:

187.20

UNSPSC Code:

12352106

NACRES:

NA.22

MDL number:

MFCD25954959

Form:

powder

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属性

form

powder

Quality Level

100

mp

68-72 °C

storage temp.

2-8°C

SMILES string

[n]2(cncc2)C(=O)c1c(nccc1)C

InChI

1S/C10H9N3O/c1-8-9(3-2-4-12-8)10(14)13-6-5-11-7-13/h2-7H,1H3

InChI key

OWQPEDNXDCVXJO-UHFFFAOYSA-N

说明

Application

2-Methylnicotinic acid imidazolide (NAI or mNAI) is an RNA SHAPE probe for live-cell RNA structure profiling. SHAPE -- or selective 2′-hydroxyl acylation analyzed by primer extension -- uses small, electrophilic chemical probes to react with the 2′-hydroxyl group and provides insight to RNA structure and its dynamics in varied cells states or in cells with gene knockouts. It has also been extended to the SHALiPE approach, selective 2′-hydroxyl acylation with lithium ion-based primer extension.

Other Notes

Conditional control of RNA-guided nucleic acid cleavage and gene editing

Guidelines for SHAPE Reagent Choice and Detection Strategy for RNA Structure Probing Studies

SnapShot: RNA Structure Probing Technologies

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA

Determination of in vivo RNA structure in low-abundance transcripts

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

MKCQ2936

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Determination of in vivo RNA structure in low-abundance transcripts.

Chun Kit Kwok et al.

Nature communications, 4, 2971-2971 (2013-12-18)

RNA structure plays important roles in diverse biological processes. However, the structures of all but the few most abundant RNAs are presently unknown in vivo. Here we introduce DMS/SHAPE-LMPCR to query the in vivo structures of low-abundance transcripts. DMS/SHAPE-LMPCR achieves

全球贸易项目编号

货号	GTIN
913839-500MG	04061842050758
913839-50MG	04061842050765