description
3β-hydroxy-5-cholestene-7-one
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 mg (700015P-100mg), pkg of 1 × 5 mg (700015P-5mg), pkg of 1 × 50 mg (700015P-50mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C)C)C)(CC3)C)C(=O)C=C2C1)C
InChI
1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,25+,26+,27-/m1/s1
InChI key
YIKKMWSQVKJCOP-ABXCMAEBSA-N
General description
7-酮胆固醇是胆固醇的主要氧化产物。
Application
<ul>
<li><strong>Cytoprotective effects of linolenic acid on 7-ketocholesterol-induced damage:</strong> 本研究揭示了特定脂肪酸如何减轻 7-酮胆固醇对神经和血管细胞的毒性作用，凸显了在神经退行性疾病和心血管疾病方面的潜在治疗应用前景(Yammine et al., 2024)。</li>
</ul>
<li><strong>Cytoprotective effects of linolenic acid on 7-ketocholesterol-induced damage:</strong> 本研究揭示了特定脂肪酸如何减轻 7-酮胆固醇对神经和血管细胞的毒性作用，凸显了在神经退行性疾病和心血管疾病方面的潜在治疗应用前景(Yammine et al., 2024)。</li>
</ul>
Biochem/physiol Actions
7-酮胆固醇是细胞色素P450 7A1的强抑制剂。 它可调节胆固醇的稳态，细胞毒性和凋亡。 7-酮胆固醇刺激炎症、抑制生长和促进血管内皮生长因子。7-酮胆固醇的细胞蓄积可增强氧化应激、内质网应激和巨噬细胞凋亡。
Packaging
5 mL 琥珀色玻璃螺旋盖小瓶 (700015P-100 mg)
5 mL 琥珀色玻璃螺旋盖小瓶 (700015P-5 mg)
5 mL 琥珀色玻璃螺旋盖小瓶 (700015P-50 mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Association of plasma 7-ketocholesterol with cardiovascular outcomes and total mortality in patients with coronary artery disease
Song J, et al.
Circulation Research, 120(10), 1622-1631 (2017)
7-Ketocholesterol
Lyons MA and Brown AJ
The International Journal of Biochemistry & Cell Biology, 31(3-4), 369-375 (1999)
Jesse A Rudd-Schmidt et al.
Nature communications, 10(1), 5396-5396 (2019-11-30)
Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTLs achieve this by forming an immunological synapse with their targets and secreting a pore-forming protein (perforin) and pro-apoptotic serine proteases (granzymes) into the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 700015P-5MG | 04061835383245 |
| 700015P-100MG | 04061835383221 |
| 700015P-50MG | 04061835383238 |