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ALD00602

(–)-PSI Reagent

Name: (–)-PSI Reagent
Brand: SIAL

95%

别名:

(2S,3aS,6R,7aS)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, (–)-Ψ, Phosphorus-Sulfur Incorporation Reagent

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₆F₅OPS₃

化学文摘社编号:

2245335-70-8

分子量:

446.46

MDL number:

MFCD32068365

UNSPSC Code:

12352101

NACRES:

NA.22

Assay:

95%

Form:

powder or crystals

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属性

assay

95%

form

powder or crystals

mp

103-107 °C

SMILES string

Fc1c(c(c(c(c1F)F)S[P]2(=S)S[C@@]3([C@@H](O2)C[C@@H](CC3)C(=C)C)C)F)F

InChI

1S/C16H16F5OPS3/c1-7(2)8-4-5-16(3)9(6-8)22-23(24,26-16)25-15-13(20)11(18)10(17)12(19)14(15)21/h8-9H,1,4-6H2,2-3H3/t8-,9+,16+,23?/m1/s1

InChI key

YPYCUYPOHPPYAS-QSHUGKRNSA-N

说明

Application

Air- and moisture-tolerant, this (-)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (+)-PSI Reagent, is also available (cat# ALD00604).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Other Notes

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

PSI on OpenFlask

Legal Information

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

Unlocking P(V): Reagents for chiral phosphorothioate synthesis.

Kyle W Knouse et al.

Science (New York, N.Y.), 361(6408), 1234-1238 (2018-08-04)

Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic

全球贸易项目编号

货号	GTIN
ALD00602-1KG	04061838479921
ALD00602-25G	04061838479983
ALD00602-500MG	04061838479938
ALD00602-100G	04061838479969
ALD00602-5G	04061838480019