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A0152000

乙酰半胱氨酸杂质C

Name: 乙酰半胱氨酸杂质C
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

N,N′-二乙酰基-L-胱氨酸, NSC 203780

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₆N₂O₆S₂

化学文摘社编号:

5545-17-5

分子量:

324.37

MDL number:

MFCD00525214

UNSPSC Code:

41116107

EC Number:

226-911-5

NACRES:

NA.24

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属性

grade

pharmaceutical primary standard

API family

acetylcysteine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

S(SCC(NC(=O)C)C(=O)O)CC(NC(=O)C)C(=O)O

InChI

1S/C10H16N2O6S2/c1-5(13)11-7(9(15)16)3-19-20-4-8(10(17)18)12-6(2)14/h7-8H,3-4H2,1-2H3,(H,11,13)(H,12,14)(H,15,16)(H,17,18)

InChI key

YTPQSLLEROSACP-UHFFFAOYSA-N

说明

General description

本品按现行药典规定交付。所有为支持本产品而提供的信息，包括 SDS 和任何产品信息小册子，均由药典颁发机构制定和发布。

如需进一步信息和支持，请访问现行药典网站。

Application

本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。不保证适用于任何其他用途，用户请自行负责。本标准品不适用于人类或动物使用。
用于制备参考溶液 (c)，根据欧洲药典各论 0967，使用气相色谱法（通则 2.2.28）测试乙酰半胱氨酸中的相关物质。

Packaging

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

Other Notes

可能适用相应的销售限制。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis.

M Wågberg et al.

The Journal of pharmacology and experimental therapeutics, 299(1), 76-82 (2001-09-19)

Oxidation of lipoprotein-derived lipids is generally accepted to be important in atherogenesis, and lipophilic antioxidants have been suggested as potential antiatherosclerotic agents. The antiatherogenic effects observed by certain antioxidants, especially probucol, in different animal models support this suggestion. There are

The new oral immunomodulating drug DiNAC induces brachial artery vasodilatation at rest and during hyperemia in hypercholesterolemic subjects, likely by a nitric oxide-dependent mechanism.

Knut Pettersson et al.

Atherosclerosis, 196(1), 275-282 (2006-12-13)

To investigate if the immunomodulator drug DINAC (1) affects arterial dimensions in asymptomatic patients with hypercholesterolemia, (2) has effects on leucocyte markers of inflammation and (3) has in vitro effects on nitric oxide synthase (NOS) in human umbilical vein endothelial

N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents.

B Särnstrand et al.

The Journal of pharmacology and experimental therapeutics, 288(3), 1174-1184 (1999-02-23)

Oral N-acetyl-L-cysteine (NAC) is used clinically for treatment of chronic obstructive pulmonary disease. NAC is easily oxidized to its disulfide. We show here that N,N'-diacetyl-L-cystine (DiNAC) is a potent modulator of contact sensitivity (CS)/delayed type hypersensitivity (DTH) reactions in rodents.

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全球贸易项目编号

货号	GTIN
A0152000	04061833799192