RDD039
咪唑
Molecular Biology, ≥99% (titration), free-flowing, Redi-Dri™
别名:
1,3-二氮杂-2,4-环戊二烯, 甘恶啉
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关于此项目
经验公式（希尔记法）:
C3H4N2
化学文摘社编号:
分子量:
68.08
NACRES:
NA.21
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
103853
MDL number:
eCl@ss:
39161001
grade
Molecular Biology
Quality Level
vapor pressure
<1 mmHg ( 20 °C)
product line
Redi-Dri™
assay
≥99% (titration)
form
crystalline powder
quality
free-flowing
pH
6.2-7.8 (25 °C)
pKa (25 °C)
6.95
bp
256 °C (lit.)
mp
88-91 °C (lit.)
application(s)
diagnostic assay manufacturing
foreign activity
DNase, RNase and protease, none detected
SMILES string
c1c[nH]cn1
InChI
1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChI key
RAXXELZNTBOGNW-UHFFFAOYSA-N
General description
Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.
Application
Imidazole has been used
- in the lysis, wash, and elution buffer for the purification of histidine tagged proteins
- in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
- as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells
特别适用于 pH 6.2-7.8 范围内的缓冲液
Biochem/physiol Actions
Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
Features and Benefits
- Qualified for molecular biology applications, DNase, Rnase, and protease free
- Redi-Dri™ packaging controls moisture, eliminating clumps
- Crystalline powder remains free-flowing and much easier to use
- Safer to handle and weigh out for routine use in lab
- Less waste, loss of drying, while maintaining high quality
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Legal Information
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
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Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
293.0 °F - closed cup
flash_point_c
145 °C - closed cup
法规信息
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Redi-Dri™ prevents hygroscopic powders, such as inorganic salts, from absorbing moisture and forming clumps, leaving the salts free-flowing every time.
Molecular pathways regulating pro-migratory effects of Hedgehog signaling
Hochman E, et al.
The Journal of Biological Chemistry, 281(45), 33860-33870 (2006)
Alan M Sandercock et al.
Molecular cancer, 14, 147-147 (2015-08-01)
Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more predictive of
Ali Tebbi et al.
The Journal of biological chemistry, 290(22), 14077-14090 (2015-04-17)
Ribonucleotide reductase (RnR) is a key enzyme synthesizing deoxyribonucleotides for DNA replication and repair. In mammals, the R1 catalytic subunit forms an active complex with either one of the two small subunits R2 and p53R2. Expression of R2 is S
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| RDD039-100G | 04061842093953 |