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Y0000002

氯化乙酰胆碱

Name: 氯化乙酰胆碱
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

ACh

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关于此项目

线性分子式:

(CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-

化学文摘社编号:

60-31-1

分子量:

181.66

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329830811

EC Number:

200-468-8

Beilstein/REAXYS Number:

3571875

MDL number:

MFCD00011698

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属性

grade

pharmaceutical primary standard

API family

acetylcholine

manufacturer/tradename

EDQM

mp

146-150 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

[Cl-].CC(=O)OCC[N+](C)(C)C

InChI

1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

InChI key

JUGOREOARAHOCO-UHFFFAOYSA-M

Gene Information

human ... CHRM3(1131)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetylcholine chloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

氯化乙酰胆碱，20mg/kg体重注射，减少小鼠实验性诱发脓毒病的死亡和血浆促炎细胞因子。类胆碱能抗-炎症机制可能通过乙酰胆碱和 α7n单核细胞，巨噬细胞和中性粒细胞上的胆红素受体互作接待，降低了促炎细胞活素，比如 TNF-α,IL-1β,和IL-6。

胆碱能突触中的内源性神经递质，通过增强肌膜动作电位来触发肌肉收缩反应。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex.

Eliane Proulx et al.

Cellular and molecular life sciences : CMLS, 71(7), 1225-1244 (2013-10-15)

Cholinergic modulation of prefrontal cortex is essential for attention. In essence, it focuses the mind on relevant, transient stimuli in support of goal-directed behavior. The excitation of prefrontal layer VI neurons through nicotinic acetylcholine receptors optimizes local and top-down control

A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors.

Sulan Luo et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1842-1853 (2014-01-09)

This study was performed to discover and characterize the first potent α3β2-subtype-selective nicotinic acetylcholine receptor (nAChR) ligand. A novel α4/7-conotoxin, α-CTxLvIA, was cloned from Conus lividus. Its pharmacological profile at Xenopus laevis oocyte-expressed rat nAChR subtypes was determined by 2-electrode

Factors influencing long-term regression after posterior chamber phakic intraocular lens implantation for moderate to high myopia.

Kazutaka Kamiya et al.

American journal of ophthalmology, 158(1), 179-184 (2014-04-05)

To evaluate the factors affecting the long-term regression after posterior chamber phakic intraocular lens (Visian ICL; STAAR Surgical) implantation for myopia. Retrospective observational case series. We retrospectively examined 60 eyes of 35 consecutive patients (age, 38.4 ± 9.3 years [mean

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货号	GTIN
Y0000002	04061837567629