D9163
DL-二硫苏糖醇
suitable for electrophoresis, ≥99%
别名:
1,4-二巯基苏糖醇, DTT, 克莱兰氏试剂
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关于此项目
线性分子式:
HSCH2CH(OH)CH(OH)CH2SH
化学文摘社编号:
分子量:
154.25
UNSPSC Code:
12161504
NACRES:
NB.22
PubChem Substance ID:
EC Number:
222-468-7
Beilstein/REAXYS Number:
1719757
MDL number:
Quality Level
assay
≥99%
form
powder
reaction suitability
reagent type: reductant
technique(s)
electrophoresis: suitable
mp
40-44 °C, 41-44 °C (lit.)
solubility
H2O: 50 mg/mL, clear, colorless to very faintly yellow
cation traces
heavy metals (as Pb): ≤10 ppm
absorption
≤0.04 at 280 at 0.02 M
storage temp.
2-8°C
SMILES string
O[C@H](CS)[C@H](O)CS
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
InChI key
VHJLVAABSRFDPM-QWWZWVQMSA-N
Application
用于将 −SH 基保持在还原态的绝佳试剂；定量还原二硫化物。在 SDS-PAGE 前，DTT 在样品缓冲液中可有效还原蛋白二硫键。DTT 还可用于还原交联剂 N,N′-双(丙烯酰)胱胺的二硫键桥以分解聚丙烯酰胺凝胶基质。DTT 的刺激性和毒性都低于 2-巯基乙醇。通常，使用 DTT (100mM) 所需的浓度是使用 2-巯基乙醇 (5% v/v, 700mM) 的浓度的七分之一。
Analysis Note
针对用于还原 SDS-PAGE 进行了测试
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Florentina Negoita et al.
Biochemical and biophysical research communications, 508(3), 775-779 (2018-12-12)
Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy
Jin-Gu Lee et al.
Nature communications, 4, 1568-1568 (2013-03-07)
In eukaryotes, deubiquitinases (DUBs) remove ubiquitin conjugates from diverse substrates, altering their stabilities, localizations or activities. Here we show that many DUBs of the USP and UCH subfamilies can be reversibly inactivated upon oxidation by reactive oxygen species in vitro
Mojtaba Abdul Roda et al.
PloS one, 9(5), e97594-e97594 (2014-05-20)
A novel neutrophil chemoattractant derived from collagen, proline-glycine-proline (PGP), has been recently characterized in chronic obstructive pulmonary disease (COPD). This peptide is derived via the proteolytic activity of matrix metalloproteases (MMP's)-8/9 and PE, enzymes produced by neutrophils and present in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D9163-25G | 04061835521814 |
| D9163-1G | 04061833590386 |
| D9163-5G | 04061833590393 |