K1639
K-252a
from Nonomuraea longicatena, ≥98% (HPLC)
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关于此项目
经验公式（希尔记法）:
C27H21N3O5
化学文摘社编号:
分子量:
467.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
biological source
Nonomuraea longicatena
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMF: 1 mg/mL, DMSO: 1 mg/mL
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InChI
1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI key
KOZFSFOOLUUIGY-SOLYNIJKSA-N
Gene Information
human ... NTRK1(4914)
rat ... Prkca(24680)
Application
K-252a 已被用于：
- 作为原肌球蛋白受体激酶（Trk）抑制剂用于研究大鼠中TrkA信号传导的作用
- 作为诱发视网膜Müller神经胶质细胞体外损伤的Trk抑制剂用于研究脐血清（ CBS）的作用
- 作为通用蛋白激酶抑制剂用于研究其对体外 人睾丸体细胞（somatic testicular cell）重组的作用
Biochem/physiol Actions
K-252a是酪氨酸蛋白激酶的选择性抑制剂。它的作用对象是IC50值在3 和25nM之间 的多种蛋白激酶以及神经营养因子受体-原肌球蛋白受体激酶。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Carmen Ciavarella et al.
PloS one, 15(6), e0234145-e0234145 (2020-06-05)
Oxidative stress and inflammation determine retinal ganglion cell degeneration, leading to retinal impairment and vision loss. Müller glial cells regulate retinal repair under injury, through gliosis. Meanwhile, reactive gliosis can turn in pathological effects, contributing to neurodegeneration. In the present
Kalsoom Sughra et al.
PloS one, 5(9), e12683-e12683 (2010-09-22)
I-kappa B kinase 2 (IKK2 or IKK-beta) is one of the most crucial signaling kinases for activation of NF-kappa B, a transcription factor that is important for inflammation, cell survival and differentiation. Since many NF-kappa B activating pathways converge at
Yun Yu et al.
Food & function, 10(9), 6009-6019 (2019-09-05)
The major bioactive ingredient THSG of Polygonum multiflorum is well established for its anti-oxidation, anti-aging and anti-inflammation properties. Increasing evidence supports the capacity of THSG to ameliorate the biochemistry of neurotrophins and their downstream signaling axis in mouse models to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| K1639-100UG | 04061833868058 |