biological source
Escherichia coli (O26:B6)
Quality Level
sterility
γ-irradiated
product line
BioXtra
form
lyophilized powder
purified by
gel-filtration chromatography
technique(s)
cell culture | mammalian: suitable
impurities
<5% Protein (Lowry)
solubility
H2O: 5 mg/mL, slightly hazy
storage temp.
2-8°C
Application
来自 大肠杆菌026:B6的脂多糖用于引发人PBMC、小鼠骨髓树突细胞 和大鼠星形胶质细胞分泌细胞因子。
脂多糖(LPS)是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4(TLR4)刺激先天免疫系统的细胞,TLR4是Toll样受体蛋白家族的成员,该家族可识别常见的病原体相关分子模式(PAMP)。
Biochem/physiol Actions
LPS是大多数革兰氏阴性细菌细胞壁的主要成分。它是一种高免疫原性抗原,可增强对可溶性抗原的免疫应答。LPS也是小鼠、兔、鸡、牛、仓鼠和人的骨髓源B淋巴细胞的特异性促分裂原。
Preparation Note
脂多糖以冻干的γ--辐射粉末形式提供。复溶时,向样品瓶(1 mg)中加1 ml无菌平衡盐溶液或组织培养基,轻轻涡旋,直至粉末溶解。可使用无菌平衡盐溶液或组织培养基将复溶产品进一步稀释至所需工作浓度。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
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Probiotic bacteria have a beneficial effect on intestinal inflammation. In this study, we have examined the effect of lactic acid and commensal Gram positive (+) bacteria conditioned media (CM) on tumour necrosis factor alpha (TNF-alpha) release and the mechanisms involved.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L2654-1MG | 04061838446268 |
