biological source
Escherichia coli (O26:B6)
Quality Level
form
lyophilized powder
purified by
gel-filtration chromatography
impurities
<5% Protein
color
white to faint yellow
solubility
water: 4.90-5.10 mg/mL, cloudy to hazy, colorless to faintly yellow
shipped in
ambient
storage temp.
2-8°C
General description
该产品是从大肠杆菌血清型 O26:B6中提取的，并已通过凝胶过滤进行纯化。源菌株是ATCC 12795。来自血清型 026的LPS：B6是来自大肠杆菌的唯一 LPS，其在SDS-PAGE 上表现出短链长行为。该 LPS的短链长度接近突变粗糙株 LPS的短链长。该LPS血清型已经以1 μg/ml用于刺激中性粒细胞。
Application
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，TLR4是Toll样受体蛋白家族的成员，该家族可识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的破坏。
Preparation Note
本品溶于水(5 mg/ml)或细胞培养基（1 mg/ml），得到浑浊的淡黄色溶液。以盐水为溶剂时，经过涡旋并加热至70-80 oC后，得到浓度更高但仍然浑浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中，可观察到混浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液，而以水为溶剂将得到均匀的混浊溶液。
Still not finding the right product?
Explore all of our products under 脂多糖 来源于大肠杆菌 026:B6
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
相关内容
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
Antonina Akk et al.
Frontiers in immunology, 7, 325-325 (2016-09-13)
Paramyxoviral infection in childhood has been linked to a significant increased rate of asthma development. In mice, paramyxoviral infection with the mouse parainfluenza virus type I, Sendai virus (Sev), causes a limited bronchiolitis followed by persistent asthma traits. We have
Randy Tatt Yhew Haw et al.
Journal of neuroinflammation, 11, 134-134 (2014-07-31)
We report a novel method of culturing microglia in three dimension (3D) using collagen as a substrate. By culturing microglia within a matrix, we aim to emulate the physical state of microglia embedded within parenchyma. BV2 microglia cell suspensions were
Paula Bertram et al.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(1), 1-6 (2015-02-28)
The complement alternative pathway (AP) is a major contributor to a broad and growing spectrum of diseases that includes age-related macular degeneration, atypical hemolytic uremic syndrome, and preeclampsia. As a result, there is much interest in the therapeutic disruption of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L2762-5MG | 04061833950371 |
| L2762-10MG | 04061833950364 |
| L2762-25MG | 04061833272237 |