T4648
凝血酶 来源于牛血浆
lyophilized powder, 40-500 NIH units/mg protein (biuret)
别名:
IIa 因子
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-648-7
MDL number:
Specific activity:
40-500 NIH units/mg protein (biuret)
Biological source:
bovine plasma
biological source
bovine plasma
Quality Level
form
lyophilized powder
specific activity
40-500 NIH units/mg protein (biuret)
mol wt
heavy chain ~33 kDa, light chain ~5 kDa
composition
Protein, 40-60%
color
, white to faint yellow to faint red
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
cow ... F2(280685)
General description
凝血酶是止血相关的最终凝血蛋白酶，对促凝血和抗凝血作用都有所促进。
Application
凝血酶可用于含有可接近的凝血酶识别位点以除去亲和标签的重组融合蛋白的位点特异性切割。凝血酶已用于一项对从脓毒性休克患者中持续性低凝状态进行评估的研究中。
Biochem/physiol Actions
丝氨酸蛋白酶，选择性断开纤维蛋白原中的精氨酸-甘氨酸键，形成纤维蛋白以及纤维蛋白肽 A 和 B。
Physical form
含有氯化钠和Tris-HCl，pH 7.0的冻干粉
Preparation Note
用牛脑促凝血酶原激酶进行激活。
Analysis Note
基于 Biggs 改性法的 NIH 分析过程使用 0.2mL 稀释血浆（由血浆与等量生理盐水混合制得）作为底物，以及 0.1mL 凝血酶样品（在含 1% 白蛋白缓冲液中保持稳定）。只使用 15-25 秒之间的凝血时间分析凝血酶浓度。
活性是通过与一种K批次的NIH凝血酶参考标准品进行直接比较而得到并以NIH单位进行表达的。
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signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
此项目有
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T4648-10KU | 04061835513246 |
| T4648-100KU | 04061835559329 |
| T4648-1KU | 04061835559336 |