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900608

APhos Pd G4

Name: APhos Pd G4
Brand: ALDRICH

95%, powder or crystals

Synonym(s):

(Methanesulfonato-κO)[2′-(methylamino)-2-biphenylyl]palladium - 4-[bis(2-methyl-2-propanyl)phosphino]-N,N-dimethylaniline

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₄₃N₂O₃PPdS

CAS Number:

2812444-73-6

Molecular Weight:

649.13

UNSPSC Code:

12161600

NACRES:

NA.22

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Properties

Product Name

APhos Pd G4, 95%

Quality Level

100

product line

Buchwald precatalyst Generation 4

assay

95%

form

powder or crystals

feature

generation 4

reaction suitability

core: palladium, reagent type: catalyst
reaction type: Cross Couplings

mp

204 °C

SMILES string

O=S(=O)([O-][Pd+2]1([C-]=2C=CC=CC2C=3C=CC=CC3[NH]1C)[P](C4=CC=C(C=C4)N(C)C)(C(C)(C)C)C(C)(C)C)C

InChI

1S/C16H28NP.C13H12N.CH4O3S.Pd/c1-15(2,3)18(16(4,5)6)14-11-9-13(10-12-14)17(7)8;1-14-13-10-6-5-9-12(13)11-7-3-2-4-8-11;1-5(2,3)4;/h9-12H,1-8H3;2-7,9-10,14H,1H3;1H3,(H,2,3,4);/q;-1;;+2/p-1

InChI key

MLEINNWTBGCQPS-UHFFFAOYSA-M

Description

Application

APhos Pd G4 is a powerful ligand for classic cross-coupling reactions combined with the Buchwald Fourth Generation Palladacycle. Bench stable, soluble in most organic solvents.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

MKCQ0156

MKCM5953

MKCH9421

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Articles

G3和G4 Buchwald预催化剂

G3和G4 Buchwald预催化剂是一类最新的空气、湿度和热稳定型交叉偶联复合物，可用于键形成以实现其多功能性和高反应性。

G3 and G4 Buchwald Precatalysts

G3 and G4 Buchwald palladium precatalysts are the newest air, moisture, and thermally stable crossing-coupling complexes used in bond formation for their versatility and high reactivity.

The Buchwald group has developed a series of highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The ligands are electron-rich, and highly tunable to provide catalyst systems with a diverse scope, high stability and reactivity. Furthermore, the new series of precatalysts are air-, moisture and thermally-stable and display good solubility in common organic solvents. The use of precatalysts ensures the efficient generation of the active catalytic species and allows one to accurately adjust the ligand:palladium ratio. The ligands, precatalysts and methodology developed in the Buchwald group are user friendly and have rendered previously difficult cross couplings reactions, much easier to achieve.

Design of New Ligands for the Palladium-Catalyzed Arylation of α-Branched Secondary Amines.

Nathaniel H Park et al.

Angewandte Chemie (International ed. in English), 54(28), 8259-8262 (2015-06-03)

In Pd-catalyzed C-N cross-coupling reactions, α-branched secondary amines are difficult coupling partners and the desired products are often produced in low yields. In order to provide a robust method for accessing N-aryl α-branched tertiary amines, new catalysts have been designed

Global Trade Item Number

SKU	GTIN
900608-250MG	04061833258033
900608-1G	04061824069242