Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C29H52O
CAS Number:
Molecular Weight:
416.72
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
sitostanol, β-sitostanol, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (700121P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700121P
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@@H]1C[C@H]2[C@@]([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](C(C)C)CC)C)(CC3)C)CC2)(CC1)C
InChI
1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1
InChI key
LGJMUZUPVCAVPU-HRJGVYIJSA-N
General description
It is predominantly present in pine oil.
Sitostanol is a 5α-saturated sitosterol derivative.
Sitostanol is a plant stanol and a hydrogenated form of sitosterol.
Application
Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies and Brewster angle microscopy studies. It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS).
Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies. It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients.
Biochem/physiol Actions
Sitostanol decreases cholesterol absorption. Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation. Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients. It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol.
Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol.
Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol. Sitostanol is known to possess hypolipidemic and antiatherogenic effects.
Packaging
5 mL Amber Glass Screw Cap Vial (700121P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population
Miettinen TA, et al.
The New England Journal of Medicine, 333(20), 1308-1312 (1995)
Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach
Brull F, et al.
Testing, 7(10), e46895-e46895 (2012)
The influence of plant stanol on phospholipids monolayers-The effect of phospholipid structure
Hkac-Wydro K, et al.
Journal of Colloid and Interface Science, 360(2), 681-689 (2011)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 700121P-5MG | 04061835383801 |