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890890P

Avanti

18:1 TAP (DOTAP)

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt), DOTAP

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About This Item

Empirical Formula (Hill Notation):
C42H80NO4Cl
CAS Number:
132172-61-3
Molecular Weight:
698.54
MDL number:
MFCD01310872
UNSPSC Code:
12352211
NACRES:
NA.25
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assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g ((890890P-1G)), pkg of 2 × 100 mg ((890890P-200MG)), pkg of 5 × 100 mg ((890890P-100MG)), pkg of 1 × 25 mg ((890890P-25MG))

manufacturer/tradename

Avanti Research™ - A Croda Brand

application(s)

advanced drug delivery

lipid type

transfection
cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

InChI

1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;

InChI key

KSXTUUUQYQYKCR-LQDDAWAPSA-M

Application

18:1 TAP (DOTAP) has been used in chloroform solutions to form dry film in the preparation of cationic liposomes. It has also been used in standard stock solution used for the preparation of cationic liposomes.

Biochem/physiol Actions

DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

5 mL Clear Glass Sealed Ampule (890890P-200mg)
5 mL Clear Glass Sealed Ampule (890890P-25mg)
5 mL Clear Glass Sealed Ampule (890890P-500mg)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (890890P-1g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis
Li Y, et al.
BMC Pharmacology & Toxicology, 19(1), 43-43 (2018)
Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
View All Related Papers

Global Trade Item Number

SKUGTIN
890890P-500MG04061835188543
890890P-1G04061835188512
890890P-200MG04061835188529
890890P-25MG04061835188536