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1.02497

NMP

Name: NMP
Brand: MM

for headspace gas chromatography SupraSolv^®

Synonym(s):

1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone

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About This Item

CAS Number:

872-50-4

Molecular Weight:

99.13

UNSPSC Code:

41116105

EC Index Number:

212-828-1

NACRES:

NA.03

MDL number:

MFCD00003193

Assay:

≥99.8% (GC)

Technique(s):

GC-HS: suitable

Bp:

202 °C/1013 hPa

Vapor pressure:

0.32 hPa ( 20 °C)

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Properties

Product Name

1-Methyl-2-pyrrolidone, for headspace gas chromatography SupraSolv^®

vapor pressure

0.32 hPa ( 20 °C)

Quality Level

100

product line

SupraSolv^®

assay

≥99.8% (GC)

form

liquid

autoignition temp.

245 °C

potency

3598 mg/kg LD₅₀, oral (Rat), 8000 mg/kg LD₅₀, skin (Rabbit)

expl. lim.

1.3-9.5 % (v/v)

technique(s)

GC-HS: suitable

pH

8.5-10.0 (20 °C, 100 g/L in H₂O)

bp

202 °C/1013 hPa

mp

-24 °C

transition temp

flash point 91 °C

solubility

1000 g/L

density

1.03 g/cm³ at 20 °C

storage temp.

2-30°C

SMILES string

N1(CCCC1=O)C

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

Description

General description

SupraSolv^® high-purity solvents are specially designed for headspace-gas chromatography (HS-GC) for the analysis of residual solvents (RS) in active pharmaceutical ingredients, excipients and drug products according to Ph. Eur and USP. The concentrations of RS for high purity solvents are specified following ICH (International Council for Harmonizaton of Technical Requirements for Registration of Pharmaceuticals for Human Use) Guideline Q3C “Impurities: Guideline for Residual Solvents”.

Application

Intended for sensitive detection of analytes of ICH classes 1, 2 and 3 in residue and environmental analysis:

Every residual solvent of class 1 acc. ICH ≤ 1 μg/g
Every residual solvent of class 2 acc. ICH ≤ 10 μg/g
Every residual solvent of class 3 acc. ICH ≤ 50 μg/g

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS07,GHS08

signalword

Danger

hcodes

H315 - H319 - H335 - H360D

pcodes

P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup

Certificates of Analysis (COA)

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Global Trade Item Number

SKU	GTIN
1024971000	04027269692629
1024970500	04027269692612
1024972500	04027269692636