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P1754

TWEEN^® 80

Name: TWEEN<SUP>®</SUP> 80
Brand: SIAL

viscous liquid

Synonym(s):

TWEEN^® 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80

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About This Item

CAS Number:

9005-65-6

UNSPSC Code:

12161900

NACRES:

NA.21

MDL number:

MFCD00082107

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Properties

Quality Level

200

biological source

Porcine (tallow), bovine (tallow)

description

non-ionic

form

viscous liquid

mol wt

micellar avg mol wt 79,000, average mol wt 1310

composition

Oleic acid, ≥58.0% (balance primarily linoleic, palmitic, and stearic acids)

aggregation number

CMC

0.012 mM (20-25°C)

viscosity

400-620 mPa.s

transition temp

cloud point 65 °C

solubility

water: soluble, clear to slightly hazy, colorless to yellow

density

1.064 g/cm³

HLB

application(s)

cell analysis

SMILES string

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

Description

General description

Tween^® 80 is a non-ionic detergent and surfactant, classified as an ester of sorbitan and oleic acid. It is a versatile compound commonly employed in various biological applications, including cell lysis, nuclei isolation, and cell fractionation. Additionally, Tween 80 finds use in stabilizing proteins and facilitating protein membrane studies. Its effectiveness stems from its membership in the polysorbate group, characterized by the combination of sorbitol and sorbitane oleic esters with polyethylene glycol chains. These structural features contribute to Tween 80′s emulsifying capabilities and a broad range of applications.

Application

TWEEN^® 80 has been used in drug vehicle solution for specific injections in mice and rats. It has been used for the determination of esterase activity in bacterial cells.

Non-ionic detergent used for selective protein extraction and isolation of nuclei from mammalian cell lines.

Biochem/physiol Actions

TWEEN^® 80 is a polysorbate surfactant which helps in stabilizing proteins and in protein membrane studies. It is regularly used for the extraction of membrane proteins and isolation of nuclei from cells.

Features and Benefits

Excellent wetting and dispersing agent
Highly versatile surfactant for your Cell Biology and Biochemical research

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Legal Information

TWEEN is a registered trademark of Croda International PLC

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Storage Class

10 - Combustible liquids

ppe

Eyeshields, Gloves

flash_point_f

>482.0 °F - Cleveland open cup

flash_point_c

> 250 °C - Cleveland open cup

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Pathogenic factors of Pseudomonas cepacia isolates from patients with cystic fibrosis.

Gessner AR and Mortensen JE

Journal of Medical Microbiology, 33, 115-115 (1990)

Handbook of Biochemistry and Molecular Biology (2010)

Insulin Aggregation at a Dynamic Solid-Liquid-Air Triple Interface.

Thibaut Frachon et al.

Langmuir : the ACS journal of surfaces and colloids, 32(49), 13009-13019 (2016-12-14)

Therapeutic proteins are privileged in drug development because of their exquisite specificity, which is due to their three-dimensional conformation in solution. During their manufacture, storage, and delivery, interactions with material surfaces and air interfaces are known to affect their stability.

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Global Trade Item Number

SKU	GTIN
P1754-10ML-KC	04061838088253
P1754-25ML	04061837602399
P1754-500ML	04061837602405
P1754-1GA	04061837602375
P1754-1L	04061837602382

Key Documents

TWEEN^® 80

viscous liquid

Select a Size

About This Item

Quality Level

biological source

description

form

mol wt

composition

aggregation number

CMC

viscosity

transition temp

solubility

density

HLB

application(s)

SMILES string

InChI

InChI key

General description

Application

Biochem/physiol Actions

Features and Benefits

Other Notes

Legal Information

Still not finding the right product?

Safety Information

Storage Class

ppe

flash_point_f

flash_point_c

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Global Trade Item Number

Key Documents

TWEEN® 80

viscous liquid

Select a Size

About This Item

Quality Level

biological source

description

form

mol wt

composition

aggregation number

CMC

viscosity

transition temp

solubility

density

HLB

application(s)

SMILES string

InChI

InChI key

General description

Application

Biochem/physiol Actions

Features and Benefits

Other Notes

Legal Information

Still not finding the right product?

Safety Information

Storage Class

ppe

flash_point_f

flash_point_c

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Global Trade Item Number

TWEEN^® 80