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PHR1094

Phenacetin melting point standard

Name: Phenacetin melting point standard
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Phenacetin, 1-Acetyl-p-phenetidin, 4′-Ethoxyacetanilide, N-(4-Ethoxyphenyl)acetamide, p-Acetophenetidide, Acetophenetidin

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About This Item

Linear Formula:

CH₃CONHC₆H₄OC₂H₅

CAS Number:

62-44-2

Molecular Weight:

179.22

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823116

EC Number:

200-533-0

Beilstein/REAXYS Number:

1869238

MDL number:

MFCD00009094

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1514008

API family

phenacetin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

~Approximately 135 °C

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCOc1ccc(NC(C)=O)cc1

InChI

1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

InChI key

CPJSUEIXXCENMM-UHFFFAOYSA-N

Description

General description

Phenacetin is a mild analgesic drug effective for the treatment of mild to moderate pain. Its analgesic property is comparable to that of aspirin.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Phenacetin may be used as a calibration standard for the development of a test for the evaluation of phenacetin by thermal analyzes methods.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Substrate of CYP1A2 and CYP2D6.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC4010 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Danger

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Muta. 2 - Skin Sens. 1 - Water-react. 2

Storage Class

4.3 - Hazardous materials which set free flammable gases upon contact with water

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Broad range purity analysis by melting point depression using a singular feature common to all DSC purity scans

Gustin GM

Thermochimica Acta, 39(2), 81-93 (1980)

Paracetamol and phenacetin

Clissold SP

Drugs, 32(4), 46-59 (1986)

Purity and heat of fusion data for environmental standards as determined by differential scanning calorimetry

Donnelly JR, et al.

Thermochimica Acta, 167(2), 155-187 (1990)

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Global Trade Item Number

SKU	GTIN
PHR1094-1G	04061835232994