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Y0000734

Dacarbazine impurity A

Name: Dacarbazine impurity A
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2-Azahypoxanthine, NSC 22419, 3,7-Dihydro-4H-imidazo[4,5-d]-1,2,3-triazin-4-one

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About This Item

Empirical Formula (Hill Notation):

C₄H₃N₅O

CAS Number:

4656-86-4

Molecular Weight:

137.10

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

grade

pharmaceutical primary standard

API family

dacarbazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N1NC(=O)C2=NC=NC2=N1

InChI

1S/C4H3N5O/c10-4-2-3(6-1-5-2)7-9-8-4/h1,9H,(H,8,10)

InChI key

WXKVKFJUCMCVFI-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dacarbazine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Simultaneous determination of dacarbazine, its photolytic degradation product, 2-azahypoxanthine, and the metabolite 5-aminoimidazole-4-carboxamide in plasma and urine by high-pressure liquid chromatography.

D Fiore et al.

Antimicrobial agents and chemotherapy, 27(6), 977-979 (1985-06-01)

A high-pressure liquid chromatographic method has been developed that allows for the simultaneous analysis of dacarbazine (DTIC), 5-aminoimidazole-4-carboxamide (AIC), and 2-azahypoxanthine (2-AZA) in plasma or urine. Plasma samples were prepared by ultrafiltration, whereas urine samples were filtered and diluted for

Disclosure of the "fairy" of fairy-ring-forming fungus Lepista sordida.

Jae-Hoon Choi et al.

Chembiochem : a European journal of chemical biology, 11(10), 1373-1377 (2010-05-21)

Role of tautomerism of 2-azaadenine and 2-azahypoxanthine in substrate recognition by xanthine oxidase.

B Hernández et al.

Journal of computer-aided molecular design, 11(2), 153-162 (1997-03-01)

The tautomerism of 2-azaadenine and 2-hypoxanthine has been examined in the gas phase and in aqueous solution. The tautomerism in the gas phase has been studied by means of semiempirical and ab initio quantum-mechanical computations, as well as density-functional calculations.

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Global Trade Item Number

SKU	GTIN
Y0000734	04061837583605