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Merck
CN

494488

N,N-Dimethylformamide

biotech. grade, ≥99.9%

Synonym(s):

DMF, NSC 5356

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About This Item

Linear Formula:
HCON(CH3)2
CAS Number:
Molecular Weight:
73.09
UNSPSC Code:
12352111
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-679-5
Beilstein/REAXYS Number:
605365
MDL number:
Assay:
≥99.9%
Grade:
biotech. grade
Bp:
153 °C (lit.)
Vapor pressure:
2.7 mmHg ( 20 °C)
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grade

biotech. grade

Quality Level

vapor density

2.5 (vs air)

vapor pressure

2.7 mmHg ( 20 °C)

assay

≥99.9%

autoignition temp.

833 °F

expl. lim.

15.2 %

impurities

≤0.0005 meq/g Titr. acid, ≤0.003 meq/g Titr. base, ≤0.005% (water), <8 ppm Free amines as dimethylamine

evapn. residue

<0.0005%

refractive index

n20/D 1.430 (lit.)

pH

7 (20 °C, 200 g/L)

bp

153 °C (lit.)

mp

−61 °C (lit.)

solubility

water: miscible

density

0.944 g/mL (lit.)

UV absorption

λ: 270 nm Amax: ≤1.0, λ: 275 nm Amax: ≤0.30, λ: 295 nm Amax: ≤0.10, λ: 310 nm Amax: ≤0.05, λ: 340 nm Amax: ≤0.01, λ: 400 nm Amax: ≤0.01

application(s)

peptide synthesis

storage temp.

room temp

SMILES string

[H]C(=O)N(C)C

InChI

1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

InChI key

ZMXDDKWLCZADIW-UHFFFAOYSA-N

General description

N,N-Dimethylformamide (DMF) is a polar organic solvent with a wide range of industrial applications. It is a precursor for numerous reactions such as formylation, aminocarbonylation, amination, amidation and cyanation. Along with phosphorus oxychloride, it forms Vilsmeier reagent used in the formylation of reactive aromatic and heteroaromatic substrates. Dielectric relaxation experiments on DMF have been conducted between 238.15K and 338.15K. The thermophysical properties of the molecular interactions between DMF and the ionic liquids, ammonium salts and imidazolium salts have been studied. The characteristics of solute-solvent interactions between ammonium nitrate and DMF have been investigated.
Our biotech solvents offer exceptional quality for reliable RNA extraction, ensuring optimal laboratory performance. With low water content and minimal residue, give clean UV spectra to minimize contamination.
  • High-Quality Biotech Solvents: Designed for optimal laboratory performance with low water content and minimal residues.
  • Ideal for RNA Extraction: Essential for genetic testing and research applications like PCR.
  • Ensures Integrity of Genetic Material: Promotes reliable and reproducible results.
  • Industry Compliant: Suitable for both academic and commercial laboratories, enhancing research efficiency.

Application

N,N-dimethylformamide (DMF) has been used for the preparation of tetraformylcavitand precursor for generating octahedral nanocontainer.
Solvent for many hydrophobic organic compounds.


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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

135.5 °F - closed cup

flash_point_c

57.5 °C - closed cup

Regulatory Information

危险化学品

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A simple one-pot multicomponent synthesis of an octahedral nanocontainer molecule.
Liu X and Warmuth R.
Nature Protocols, 2(5), 1288-1296 (2007)
Volumetric properties of ammonium nitrate in N,N-dimethylformamide.
Vranes M, et al.
The Journal of Chemical Thermodynamics, 54, 245-249 (2012)
Measurements and molecular interactions for N,N-dimethylformamide with ionic liquid mixed solvents.
Attri P, et al.
The Journal of Physical Chemistry B, 114(18), 6126-6133 (2010)



Global Trade Item Number

SKUGTIN
494488-20L-P204061838227942
494488-50L-P204061838152497
494488-6X1L04061838161789
494488-PZ04061824681017
494488-10L04061838111357
494488-1L04061832408712
494488-200L04061836608545
494488-20L-N204061838161772
494488-2L04061832408729
494488-400L04061838227959
494488-56L04061836608552
494488-56L-P1-LS04061838227997
494488-AT-20L-NP04065268977781