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P3032

Penicillin G sodium salt

Name: Penicillin G sodium salt
Brand: SIGMA

powder, suitable for cell culture, BioReagent

Synonym(s):

Benzylpenicillin sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₇N₂NaO₄S

CAS Number:

69-57-8

Molecular Weight:

356.37

NACRES:

NA.76

PubChem Substance ID:

24898384

eCl@ss:

34010400

UNSPSC Code:

12352207

EC Number:

200-710-2

MDL number:

MFCD00069666

Beilstein/REAXYS Number:

3834217

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Properties

Product Name

Penicillin G sodium salt, powder, BioReagent, suitable for cell culture

product line

BioReagent

Quality Level

200

form

powder

potency

≥1477 units per mg

technique(s)

cell culture | mammalian: suitable

solubility

H₂O: 100 mg/mL

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

InChI

1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChI key

FCPVYOBCFFNJFS-LQDWTQKMSA-M

Description

General description

Chemical structure: β-lactam

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for extended periods. Solutions are stable at 37°C for 3 days.

Application

Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. It has been used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility and in cell culture both alone and combined with streptomycin and other antibiotics.

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Other Notes

1mu,10mu,25mu,100mu

Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin Keep in a dry place.

Disclaimer

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H₂O at 100 mg/mL.

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pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品

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Articles

Inhibition of Cell Wall Biosynthesis by Antibiotics

β-lactam antibacterials inhibit transpeptidase enzymes, preventing peptidoglycan assembly in both Gram-positive and Gram-negative bacteria.

nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep.

Paul P Drury et al.

Neuropharmacology, 83, 62-70 (2014-04-15)

Basal ganglia injury after hypoxia-ischemia remains common in preterm infants, and is closely associated with later cerebral palsy. In the present study we tested the hypothesis that a highly selective neuronal nitric oxide synthase (nNOS) inhibitor, JI-10, would improve survival

The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare.

Ana Amaral et al.

Frontiers in veterinary science, 7, 582211-582211 (2020-11-17)

Although proteases found in neutrophil extracellular traps (NETs) have antimicrobial properties, they also stimulate collagen type 1 (COL1) production by the mare endometrium, contributing for the development of endometrosis. Cathepsin G (CAT), a protease present in NETs, is inhibited by

Desensitization of metastatic melanoma cells to therapeutic treatment through repeated exposure to dacarbazine.

Fleury Augustin Nsole Biteghe et al.

Journal of photochemistry and photobiology. B, Biology, 211, 111982-111982 (2020-09-01)

Aberrant anti-cancer drug efflux mediated by membrane protein ABC transporters (ABCB5 and ABCG2) is thought to characterize melanoma heterogeneous chemoresistant populations, presumed to have unlimited proliferative and self-renewal abilities. Therefore, this study primarily aimed to investigate whether continuous exposure of

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Global Trade Item Number

SKU	GTIN
P3032-25MU	04061835569106
P3032-100MU	04061835569083
P3032-10MU	04061835569090
P3032-1MU	04061835514229
P3032-20MU	04061832315065
P3032-3MU	04061832315072