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P3972

Progesterone

Name: Progesterone
Brand: SIGMA

meets USP testing specifications

Synonym(s):

4-Pregnene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₀O₂

CAS Number:

57-83-0

Molecular Weight:

314.46

UNSPSC Code:

41116107

NACRES:

NA.21

PubChem Substance ID:

24898476

EC Number:

200-350-6

Beilstein/REAXYS Number:

1915950

MDL number:

MFCD00003658

Assay:

≥97%

Form:

solid

Quality level:

200

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Properties

Quality Level

200

agency

USP/NF, meets USP testing specifications

assay

≥97%

form

solid

mp

128-132 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Description

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Other Notes

Steroid hormone produced by the corpus luteum.

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pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

pcodes

P202 - P260 - P263 - P264 - P280 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品

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Articles

LC-MS法分析自来水中的激素

Milli-Q®超纯水系统产水不含有机污染物，包括实验室自来水中的激素，非常适合高度灵敏的LC-MS/MS分析。

LC-MS Analysis of Hormones in Tap Water

Milli-Q® ultrapure water systems deliver water free of organic contaminants , including hormones present in a lab's tap water, making it suitable for the most sensitive LC-MS/MS analyses.

Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells.

Koji Mizuhashi et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(8), 1387-1392 (2019-03-20)

The growth plate provides a substantial source of mesenchymal cells in the endosteal marrow space during endochondral ossification. The current model postulates that a group of chondrocytes in the hypertrophic zone can escape from apoptosis and transform into cells that

Premenopausal serum sex hormone levels in relation to breast cancer risk, overall and by hormone receptor status - results from the EPIC cohort.

Rudolf Kaaks et al.

International journal of cancer, 134(8), 1947-1957 (2013-10-25)

Results from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC)

Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC).