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925225

KB02yne

Name: KB02yne
Brand: ALDRICH

别名:

2-Chloro-1-(6-(hex-5-yn-1-yloxy)-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one, Functionalized scout fragment

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关于此项目

经验公式（希尔记法）:

C₁₇H₂₀ClNO₂

化学文摘社编号:

2376152-06-4

分子量:

305.80

MDL number:

MFCD00003568

NACRES:

NA.22

UNSPSC Code:

12352101

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属性

form

powder or crystals (or Solid or Liquid)

Quality Level

100

reaction suitability

reagent type: chemical modification reagent
reaction type: click chemistry

storage temp.

2-8°C

说明

Application

KB02yne is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131).

Related useful products may include:

Cysteine-reactive fragments: KB02 (912131), KB03 (912654), KB05 (911798), sulfoxide (925136), CoLDR probe (923818)
Functionalized scout fragments: KB02-COOH (925047), KB05yne (925144)
Electrophilc degraders featuring scout fragments: KB02-SLF (914738), KB03-SLF (914975), KB05-SLF (913715), Biotin-SLF (914223)
Cysteine-reactive probes for chemoproteomics: IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059)

Technology spotlight: Proteomic Ligandability Assessment

Other Notes

Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization

The Proteome-Wide Potential for Reversible Covalency at Cysteine

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

存储类别

10 - Combustible liquids

wgk

WGK 3

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The Proteome-Wide Potential for Reversible Covalency at Cysteine.

Kristine Senkane et al.

Angewandte Chemie (International ed. in English), 58(33), 11385-11389 (2019-06-22)

Reversible covalency, achieved with, for instance, highly electron-deficient olefins, offers a compelling strategy to design chemical probes and drugs that benefit from the sustained target engagement afforded by irreversible compounds, while avoiding permanent protein modification. Reversible covalency has mainly been

全球贸易项目编号

货号	GTIN
925225-10MG	04065267461014