biological source
Escherichia coli (O55:B5)
Quality Level
form
lyophilized powder
purified by
gel-filtration chromatography
impurities
<3% Protein
color
white to faint gray
solubility
water: soluble
shipped in
ambient
storage temp.
2-8°C
General description
这种产品是从大肠杆菌中提取的大肠杆菌血清型O55：B5，通过凝胶过滤纯化。源菌株是CDC 1644-70。脂多糖O55：B5已被用于以1纳克/毫升刺激人腹膜巨噬细胞，并以1-100纳克/毫升刺激马腹膜巨噬细胞。
Application
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。脂多糖及其脂质 A 部分通过 Toll 样受体 4（TLR4）刺激先天免疫系统的细胞，Toll 样受体 4是 Toll 样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖位于膜的外层，在非包膜菌株中，暴露在细胞表面。它们有助于外膜的完整性，保护细胞免受胆盐和亲脂性抗生素的作用。
Preparation Note
该产品可溶于水（5毫克/毫升）或细胞培养基（1毫克/毫升），产生一种朦胧的淡黄色溶液。在涡旋并升温至70-80 oC温度后，在盐水中获得了更浓但仍模糊的溶液（20毫克/毫升）脂多糖是在每种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中观察到混浊的溶液。有机溶剂不能提供更清晰的溶液。甲醇产生带有漂浮物的混浊悬浮液，而水产生均匀混浊的溶液。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
相关内容
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
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Human milk oligosaccharides (HMO) are being studied by different groups exploring a broad range of potential beneficial effects to the breastfed infant. Many of these effects have been attributed to a growth promotion effect on certain gut organisms such as
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Neutrophil granulocytes are innate effector cells of the first line of defense against pyogenic bacteria. Neutrophil lifespan is short, is prolonged by pro-inflammatory stimuli, controls functionality of the cells and can determine tissue damage. Experimental analysis of primary neutrophils is
Francisco J Quintana et al.
PloS one, 3(10), e3509-e3509 (2008-10-24)
B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies. Toll-like receptors (TLRs) also provide co-stimulation, but the requirement for TLRs to generate
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L2637-10MG | 04061833950258 |
| L2637-25MG | 04061833950265 |
| L2637-5MG | 04061833950272 |