biological source
Escherichia coli (O55:B5)
Quality Level
form
lyophilized powder
purified by
phenol extraction
technique(s)
cell based assay: suitable
impurities
<3% Protein (Lowry)
color
off-white to tan
solubility
water: soluble
application(s)
cell analysis
clinical research
life science and biopharma
shipped in
ambient
storage temp.
2-8°C
General description
脂多糖 (LPS) 是糖脂，由连接单个或多个脂肪酸的碳水化合物单元组合而成，存在于革兰氏阴性菌细胞壁中。LPS是外膜的重要组成部分，结构由脂质A、葡萄糖胺基磷脂、短核寡糖和O-抗原（远端多糖）组成。
Application
来自大肠杆菌O55:B5的脂多糖已用于：
- 刺激肝细胞和非实质细胞
- 刺激脾脏并研究Malitaf基因在鱼钝头鲷中的表达
- 作为伴刀豆球蛋白A（ConA）和D-半乳糖胺/脂多糖（D-GalN/LPS）暴发性肝炎模型的一部分用于研究天然化合物橙皮素的作用
- 诱导少突胶质细胞毒性，以评估几种化合物的神经保护作用
- 诱导大鼠肌少症，以评估载姜黄素疏水表面改性羟基磷灰石的抗氧化作用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。脂多糖及其脂质 A 部分通过 Toll 样受体 4（TLR4）刺激先天免疫系统的细胞，Toll 样受体 4是 Toll 样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖 (LPS) 建立起保护性渗透屏障，阻止抗生素和胆汁盐进入，从而使革兰氏阴性菌具备天然耐药性。LPS影响细菌致病性，毕竟宿主免疫系统主要面对的是细菌LPS成分。LPS是一种内毒素兼高免疫原性抗原，可以增强免疫系统。LPS 的脂质 A 通过 Toll 样受体 4 (TLR4) 刺激宿主细胞。
Other Notes
无论采用什么容器，本品(LPS)都要经过剧烈的涡旋振荡才能达到最佳的复溶效果，以备使用。储存液浓度至少为1 mg/ml。推荐使用硼硅酸（硅烷化）容器，也可使用聚丙烯(PP)塑料容器。
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Hazard Classifications
Acute Tox. 2 Oral
signalword
Danger
hcodes
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L2880-100MG | 04061838446275 |
| L2880-10MG | 04061838446282 |
| L2880-25MG | 04061838446299 |
| L2880-500MG | 04061838446305 |