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913979

Biotin-Thalidomide

≥95%

Synonym(s):

N1-(4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide, Biotin-conjugated thalidomide, bio-Thal

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About This Item

Empirical Formula (Hill Notation):
C44H64N8O13S
CAS Number:
2230857-87-9
Molecular Weight:
945.09
MDL number:
MFCD32851674
UNSPSC Code:
12352200
NACRES:
NA.22
Assay:
≥95%
Form:
powder
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ligand

thalidomide

Quality Level

100

assay

≥95%

form

powder

storage temp.

−20°C

SMILES string

O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3OCC(NCCCCNC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]4[C@](NC(N5)=O)([H])[C@]5([H])CS4)=O)=O)=O)=O)=O)NC1=O

InChI

1S/C44H64N8O13S/c53-34(12-2-1-11-33-40-30(28-66-33)49-44(61)51-40)46-19-7-21-62-23-25-64-26-24-63-22-8-20-47-36(55)14-6-13-35(54)45-17-3-4-18-48-38(57)27-65-32-10-5-9-29-39(32)43(60)52(42(29)59)31-15-16-37(56)50-41(31)58/h5,9-10,30-31,33,40H,1-4,6-8,11-28

InChI key

UCTZYEDSVDZJQR-NTZPKYJMSA-N

Application

Biotin-Thalidomide (bio-Thal) is a cereblon affinity probe for PROTAC® and targeted protein degradation research. Bio-Thal can be used in cereblon (CRBN) binding and displacement assays for protein degrader validation experiments, CRBN ligand discovery, competition analyses, or where enrichment of CRBN complexes is required.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

The dTAG system for immediate and target-specific protein degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM4001

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Global Trade Item Number

SKUGTIN
913979-5MG04061842097555