ALD00604
(+)-PSI试剂
95%
别名:
(+)-Ψ, (2R,3aR,6S,7aR)-3a-甲基-2-((全氟苯基)硫基)-6-(丙-1-烯-2-基)六氢苯并[d][1,3,2] 草硫磷2-硫化物, 磷硫掺入试剂
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关于此项目
经验公式（希尔记法）:
C16H16F5OPS3
化学文摘社编号:
分子量:
446.46
MDL number:
UNSPSC Code:
12352101
NACRES:
NA.22
Assay:
95%
Form:
powder or crystals
assay
95%
form
powder or crystals
mp
102-107 °C
SMILES string
Fc1c(c(c(c(c1F)F)S[P]2(=S)S[C@]3([C@H](O2)C[C@H](CC3)C(=C)C)C)F)F
InChI key
YPYCUYPOHPPYAS-DWBMIXFYSA-N
Application
耐空气和湿气的(+)-PSI试剂是在Baran实验室开发用于立体控制合成硫代磷酸酯寡核苷酸。也可提供其对映体(−)-PSI试剂（货号ALD00602）。
正如Baran实验室在制备环二核苷酸（CDN）和反义寡核苷酸（ASO）的纯立体异构体中所证明的那样，PSI试剂打开了通向具有治疗前景的硫代磷酸酯基核苷酸分子的大门。
了解更多有关 PI和PSI 试剂的信息
正如Baran实验室在制备环二核苷酸（CDN）和反义寡核苷酸（ASO）的纯立体异构体中所证明的那样，PSI试剂打开了通向具有治疗前景的硫代磷酸酯基核苷酸分子的大门。
了解更多有关 PI和PSI 试剂的信息
Other Notes
Legal Information
PCT/US2019/027256；美国非临时专利申请#16/382,692
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.
Kyle W Knouse et al.
Science (New York, N.Y.), 361(6408), 1234-1238 (2018-08-04)
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| ALD00604-100G | 04061838510884 |
| ALD00604-25G | 04061838510877 |
| ALD00604-1KG | 04061838510860 |
| ALD00604-500MG | 04061838510938 |
| ALD00604-5G | 04061838510891 |