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850365P

Avanti

18:0 PC (DSPC)

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; DSPC; PC(18:0/18:0)

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About This Item

Empirical Formula (Hill Notation):
C44H88NO8P
CAS Number:
816-94-4
Molecular Weight:
790.15
MDL number:
MFCD00036905
UNSPSC Code:
51191904
NACRES:
NA.25
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description

1,2-distearoyl-sn-glycero-3-phosphocholine

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850365P-1G), pkg of 1 × 200 mg (850365P-200MG), pkg of 1 × 25 mg (850365P-25MG), pkg of 1 × 500 mg (850365P-500MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

application(s)

advanced drug delivery

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChI key

NRJAVPSFFCBXDT-HUESYALOSA-N

General description

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons. It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC).
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:0 PC (DSPC) has been used:
  • in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts
  • in the preparation of liposomes for immobilization studies
  • in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system. It is majorly used in conventional and stealth liposome preparation for drug delivery studies.

Packaging

20 mL Clear Glass Screw Cap Vial (850365P-1G)
20 mL Clear Glass Screw Cap Vial (850365P-500MG)
5 mL Amber Glass Screw Cap Vial (850365P-200MG)
5 mL Amber Glass Screw Cap Vial (850365P-25MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Comparative study of PEGylated and conventional liposomes as carriers for shikonin
Tsermentseli S, et al.
Fluids, 3(2), 36-36 (2018)
Investigating the structure of multicomponent gel-phase lipid bilayers
Hartkamp R, et al.
Biophysical Journal, 111(4), 813-823 (2016)
A coarse-grained molecular dynamics study of DLPC, DMPC, DPPC, and DSPC mixtures in aqueous solution
Abedi K, et al.
Journal of Chemistry, 2013 (2013)
View All Related Papers

Global Trade Item Number

SKUGTIN
850365P-1G04061835230471
850365P-200MG04061835230488
850365P-25MG04061835230495
850365P-500MG04061835230501
850365P-5G04065273778410