900605
3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride
≥95%
Synonym(s):
Bromo sulfonyl fluoride alkyne, Probe building block
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About This Item
Empirical Formula (Hill Notation):
C12H14BrFO2SSi
CAS Number:
Molecular Weight:
349.29
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22
Assay:
≥95%
Form:
solid
Quality Level
assay
≥95%
form
solid
reaction suitability
reaction type: click chemistry
storage temp.
−20°C
SMILES string
[Si](C)(C)(C)C#Cc1cc(cc(c1)CBr)[S](=O)(=O)F
InChI
1S/C12H14BrFO2SSi/c1-18(2,3)5-4-10-6-11(9-13)8-12(7-10)17(14,15)16/h6-8H,9H2,1-3H3
InChI key
QSYGHPYMWBAJRL-UHFFFAOYSA-N
Application
3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 900605-100MG | 04061833250488 |