900847
4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid
≥95%
Synonym(s):
Carboxyl sulfonyl fluoride TMS-alkyne, Probe building block
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About This Item
Empirical Formula (Hill Notation):
C12H13FO4SSi
CAS Number:
Molecular Weight:
300.38
UNSPSC Code:
12352106
NACRES:
NA.22
Assay:
≥95%
Form:
powder or crystals
assay
≥95%
form
powder or crystals
storage temp.
−20°C
SMILES string
OC(C1=CC(C#C[Si](C)(C)C)=C(S(F)(=O)=O)C=C1)=O
Application
4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 900847-50MG | 04061833251218 |