900858
2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid
≥95%
Synonym(s):
Carboxyl diazirine alkyne, Probe building block
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About This Item
Empirical Formula (Hill Notation):
C12H7F3N2O3
CAS Number:
Molecular Weight:
284.19
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
Assay:
≥95%
Form:
powder
Quality Level
assay
≥95%
form
powder
reaction suitability
reaction type: click chemistry
storage temp.
−20°C
SMILES string
C#CCOC1=CC(C2(N=N2)C(F)(F)F)=CC=C1C(O)=O
InChI
1S/C12H7F3N2O3/c1-2-5-20-9-6-7(3-4-8(9)10(18)19)11(16-17-11)12(13,14)15/h1,3-4,6H,5H2,(H,18,19)
InChI key
NNGSWZWUOPOVNB-UHFFFAOYSA-N
Application
2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid is used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 900858-25MG | 04061833251249 |