Skip to Content
Merck
CN

Key Documents

View All Documentation

850725P

Avanti

18:1 (Δ9-Cis) PE (DOPE)

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; DOPE; PE(18:1(9Z)/18:1(9Z)); 110635, DOPE

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C41H78NO8P
CAS Number:
4004-05-1
Molecular Weight:
744.03
MDL number:
MFCD02259123
UNSPSC Code:
51191904
NACRES:
NA.25
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

description

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850725P-1g), pkg of 2 × 100 mg (850725P-200mg), pkg of 5 × 100 mg (850725P-500mg), pkg of 1 × 25 mg (850725P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

application(s)

advanced drug delivery

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

InChI

1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1

InChI key

MWRBNPKJOOWZPW-NYVOMTAGSA-N

General description

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.

Application

18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies. It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) forms a stable lipid layer and rapidly fuses with endosomal lipid bilayer. DOPE in combination with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) has high in vitro transfection efficiency.

Packaging

20 mL Clear Glass Screw Cap Vial (850725P-1g)
5 mL Clear Glass Sealed Ampule (850725P-200mg)
5 mL Clear Glass Sealed Ampule (850725P-25mg)
5 mL Clear Glass Sealed Ampule (850725P-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Still not finding the right product?

Explore all of our products under 18:1 (Δ9-Cis) PE (DOPE)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Specific interaction of the human mitochondrial uncoupling protein 1 with free long-chain fatty acid
Zhao L, et al.
Structure, 25(9), 1371-1379 (2017)
The role of the helper lipid on the DNA transfection efficiency of lipopolyplex formulations
Du Z, et al.
Scientific Reports, 4(2), 7107-7107 (2014)
Membrane reshaping by micrometric curvature sensitive septin filaments
Beber A, et al.
Nature Communications, 10(1), 420-420 (2019)
View All Related Papers

Global Trade Item Number

SKUGTIN
850725P-25MG04061835231218
850725P-500MG04061835231225
850725P-1G04061835231195
850725P-200MG04061835231201